A.G.E. Pill Ingredients and What They Do For You

Aging is an accumulation of things that happen at a cellular level as we live longer.  The aging process is not a disease – it is simply the decay and degeneration of our cells, resulting in reduced functionality. This process beings at age 23 in women and 25 in men. We lose about 8-10% of our physical being and biological functions every ten years.

The Chinese knew how to slow down aging 1000’s of years ago.  By removing toxins and wastes and assimilating super nutrients that are specialized for certain biological processes, the body has the ability to live a very long time. Sisel’s AGE pill does this in three different, yet synergistic, ways.  Firstly, it ends cell decay; second, it eliminates waste within the cell and third, it regenerates stem cells.

The following is a brief break down of just some of the ingredients in the AGE pill. Not all can be revealed for proprietary reasons. Before we start . . . Here is a video on only one of the ingredients that are used in THE AGE PILL. Other ingredients are even more powerful but we don’t want to reveal all of them at this time and what they do.



Beta-alanine is a naturally occurring beta amino acid that is converted to other chemicals that can then affect the muscles. This has been shown to enhance muscular endurance. Beta- Alanine supplementation can also improve moderate to high intensity cardiovascular exercise performance, like rowing or sprinting. When beta-alanine is ingested, it turns into the molecule carnosine, which acts as an acid buffer in the body.  Carnosine is stored in cells and releases in response to drops in the pH.  Increased stores of carnosine can protect against diet induced drops in the pH as well as offer protection from exercise induced lactic acid production.  Carnosine also shows reduction of oxidative stress and glycation products.  Rated one of the number one protein supplements for muscle support.

Alpha-Lipoic Acid (ALA)

-is found in the body and also synthesized by plants and animals. Its present in every cell of the body and helps turn glucose into fuel for the body to run off of.  Its most valuable role is fighting the effects of free radicals which are dangerous chemical reaction byproducts that form during the process of oxidation.  Within our cells, ALA is converted into dihydrolipoic acid, which has protective effects over normal cellular reactions. Like other antioxidants ALA can help to slow down cellular damage that is one of the root causes of diseases like cancer, heart disease and diabetes.  It also works in the body to restore essential vitamin levels, such as vit E and Vit C, along with helping the body digest and utilize carbohydrate molecules while turning them into usable energy.

ALA is both water soluble and fat soluble unlike other nutrients which can only be properly absorbed with either one or the other.  There is some evidence that ALA acts as a heavy metal chelator, binding metals in the body.  ALA can increase how the body uses glutathione, and it might increase energy metabolism as well- which is why this supplement is often used by athletes to enhance physical performance.

ALA can protect cells and neurons involved in hormone production, one benefit is it offers protection against diabetes. Because alpha lipoic acid can protect cells and neurons involved in hormone production, one benefit is it offers protection against diabetes. ALA is considered an effective drug in the treatment of diabetic distal sensory-motor neuropathy, which affects about 50 percent of people with diabetes. (5) In dietary supplement form, ALA seems to help improve insulin sensitivity and might also offer protection against metabolic syndrome — a term given to a cluster of conditions like high blood pressure, cholesterol and body weight. Some evidence also shows that it can help lower blood sugar levels.

ALA is used to help relieve complications and symptoms of diabetes caused by nerve damage, including numbness in the legs and arms, cardiovascular problems, eye-related disorders, pain, and swelling. That’s why it should be part of any diabetic diet plan to treat this common disorder. People who experience peripheral neuropathy as a side effect of diabetes can find relief from pain, burning, itching, tingling and numbness using ALA, although most studies show that high doses in IV form are most effective as opposed to eating ALA-rich foods.

A major benefit of alpha lipoic supplementation in diabetics is the lowered risk for neuropathic complications that affect the heart, since around 25 percent of people with diabetes develop cardiovascular autonomic neuropathy (CAN). CAN is characterized by reduced heart rate variability and is associated with an increased risk of mortality in people with diabetes. Oxidative stress can damage nerves in the eyes and cause vision problems, especially in people with diabetes or older adults. Alpha lipoic acid has been used successfully to help control symptoms of eye-related disorders, including vision loss, macular degeneration, retina damage, cataracts, glaucoma and Wilson’s disease.

Results from certain studies demonstrate that long-term use of alphalipoic acid has beneficial effects on the development of retinopathy since it halts oxidative damage that can result in modified DNA in the retina.

DMAE (dimethylaminoethanol)

DMAE is a substance naturally produced in small amounts in the brain and also found in anchovies and sardines. DMAE supplements are promoted to boost brainpower, improve memory, and slow aging. The idea that DMAE can improve memory stems from research suggesting it may increase levels of the neurotransmitter acetylcholine, which is believed to play an important role in learning and memory.

Levels of acetylcholine decline among people with Alzheimer’s disease, and the drugs used to treat Alzheimer’s patients target the processes that break it down. DMAE has also been studied as a means of relieving the symptoms of tardive dyskinesia, a spastic disorder that is a side-effect of long-term use of some anti-psychotic medications. Despite some promising preliminary studies, subsequent research failed to confirm that DMAE had any effect.

DMAE Bitartrate is a powdered form of the compound Dimethylaminoethanol (also known as DMAE or Deanol), a naturally occurring compound in the brain. DMAE is a precursor to the neurotransmitter choline. … Choline has been shown to directly influence the areas of learning and memory.  DMAE bitatrate is particularly beneficial for your memory function cal also increase mental adaptability, concentration, brain cell health and give you better analytic processing skills as well. DMAE is a compound that is known as a mind health compound.

It does this by reducing buildup of what is known as the ‘age pigment’, which impairs cognitive function and is implicated in the cognitive decline with age. It can also increase levels of the compound involved with memory, acetylcholine.

It can also protect neurons and other cells from harmful effects of certain types of oxidation by embedding itself in the structure of the cell and acting as an anti-oxidant, as well as sustaining metabolic processes in the body through a process known as ‘methyl donation’.

DMAE is also found in various face and body creams, and can tighten and tone skin quality.


Carnosine (beta-alanyl-L-histidine), featuring the characteristic Imidazole-ring, is a dipeptide molecule, made up of the amino acids beta-alanine and histidine. It is highly concentrated in muscle and brain tissues. L-Carnosine acts as an anti-glycating agent, reducing the rate of formation of advanced glycation end-products (AGEs) (substances that can be a factor in the development or worsening of many degenerative diseases, such as diabetes, atherosclerosis, chronic renal failure, and Alzheimer’s disease), and ultimately reducing development of atherosclerotic plaque build-up.

Chronic glycolysis is speculated to accelerate aging, making L-Carnosine a candidate for therapeutic potential. L-carnosine, sometimes called simply carnosine, is a combination of two amino acids, alanine and histidine. Your body manufactures carnosine, found in high concentrations in skeletal muscle, the lenses of the eyes, the brain and the nervous system. Carnosine acts as an anti-oxidant, a substance that neutralizes free radicals, which damage cells. potential benefits on the fact that carnosine inhibits advanced glycation end products, called AGEs, which contribute to Alzheimer’s disease.

One study found that in rat lenses exposed to substances that induce cataract formation and carnosine, carnosine prevented or reversed cataracts (Biochemistry study 5/14/2009). L-Carnosine may be recommended as an adjunct therapy for diabetes mellitus or autism. This supplement has also been researched for its antiglycation, antioxidant, cardioprotective, anticancer and antidiabetic effects.  In humans, carnosine is naturally found in the brain, skeletal muscles, the heart and certain other innervated organs and tissues.

L-Carnosine supports athletic performance and muscle vitality as well. A number of experiments carried out in Australia showed that Carnosine reinvigorates cells as they approach senescence (the stage just before they die when the cell is not functioning). Cells were given Carnosine actually looked and behaved younger than untreated cell’s .

Importantly, Carnosine reversed the signs of aging in these senescent (nearly dead) cells. This means that Carnosine is a great for older people who want to look younger, as well as those who want to continue looking younger.

L-Carnosine limits the formation of oxidized sugars, commonly known as Advanced Glycosylation End-products (AGEs) by acting as an antioxidant. From an anti-aging perspective, the fewer AGEs created in your body the better. Carnosine prevents lipid, DNA, and protein damage by removing harmful metals via chelation. Carnosine may prevent Alzheimer’s by counteracting the build up of aldehydes and amyloid plaques, which are widely considered to be the primary causes of Alzheimer’s .

The aggregation of beta amyloid into fibrillar structures contributed to Alzheimer’s disease. Carnosine was found to impede the formation of fibrillar structures by altering the hydrogen bond network involved in fibrillogenesis .  By protecting the brain against free radicals and advanced glycation end products carnosine may provide a useful tool for tackling alzheimers.

Betaine Hcl

Betaine hydrochloride is an acidic form of betaine, a vitamin-like substance found in grains and other foods. Betaine hydrochloride is recommended by some doctors as a supplemental source of hydrochloric acid for people who have a deficiency of stomach acid production (hypochlorhydria). In biological systems, many naturally occurring betaines serve as organic osmolytes, substances synthesized or taken up from the environment by cells for protection against osmotic stress, drought, high salinity or high temperature.

Intracellular accumulation of betaines, non-perturbing to enzyme function, protein structure and membrane integrity, permits water retention in cells, thus protecting from the effects of dehydration. It is also a methyl donor of increasingly recognised significance in biology.

Acetyl L-Carnitine

sisel AGE pillAcetyl L-carnitine (ALC) is an amino acid that’s primarily used by the body for energy production but also helps create acetylcholine, a brain chemical associated with memory and cognitive function.* It’s been shown to help mental fatigue associated with aging.*

Acetyl-L-Carnitine is an amino acid the body uses to turn fat into energy. It is not normally considered an essential nutrient because the body can manufacture all it needs. However, supplemental L-Carnitine may improve the ability of certain tissues to produce energy. This effect has led to the use of L-Carnitine in various muscle diseases as well as heart conditions.

Additionally, a preliminary study suggests that L-Carnitine may be useful for improving blood sugar control in individuals with type 2 (adult-onset) diabetes. It also might help prevent diabetic cardiac autonomic neuropathy (injury to the nerves of the heart caused by diabetes). Weak evidence suggests that L-Carnitine may be able to improve cholesterol and triglyceride levels, and also help individuals with degeneration of the cerebellum (the structure of the brain responsible for voluntary muscular movement).

One very small study suggests L-Carnitine may be helpful for reducing symptoms of chronic fatigue syndrome. Another study suggests that L-Carnitine may be of value for treating hyperthyroidism.  Acetyl L-carnitine Hcl is a potent super nutrient that supports the body in the same wat as L-carnitne but also has the ability to pass through the blood brain barrier.  Supports mental sharpness by stimulating acetylcholine production.  It has been shown to help maintain cellular stability and to promote cell membrane health. Acetyl L-Carnitine HCL Research

Cellular energy production itself produces free radicals that can harm cell structures, including the mitochondria, if the body’s natural antioxidant capacity is low. Acetyl l-carnitine and lipoic acid are both naturally present antioxidants in the body that have been shown to support mitochondrial function and help reduce free radical damage.

(Hagen TM et al., 1998; Lyckesfeldt J et al., 1998) Acetyl l-carnitine HCL enhances energy production by promoting the transport of fatty acids into the energy-producing units in the cells. In two animal studies from the University of California at Berkeley (Hagen TM et al., 1998) acetyl l-carnitine significantly benefited mitochondrial health and promoted increased cellular respiration and membrane health.

L-5-Hydroxytryptophan (5-HTP)

5-HTP is the precursor of the neurotransmitter serotonin. 5-HTP is obtained from the seeds of the plant Griffonia simplicifolia. also known as oxitriptan (INN), is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin.

5-HTP has been suggested as a treatment for many conditions. Some research supports the use of 5-HTP in treating cerebellar ataxia, headache, depression, psychiatric disorders, and fibromyalgia, and as an appetite suppressant or weight loss agent. Parkinson’s disease is a neurological disorder that usually develops around the age of 50. The disorder occurs when the brain cells that make dopamine slowly degenerate. Symptoms include tremors (shaking) and difficulties with movement and coordination. 5-HTP has been studied, usually in combination with drugs, for Parkinson’s disease.

Widely used to help with obesity (dieting), PMS, migraines, depression, anxiety, insomnia and addictive behaviour, 5 HTP increases production of serotonin. Serotonin levels in the nervous system are essential for so many aspects of our daily lives. Serotonin is responsible for feelings of well being, satisfaction and for normal sleep patterns. Obesity, PMS, migraines, depression, anxiety, insomnia and addictive behavior have all been associated with low levels of serotonin. Serotonin plays an important role in controlling anger, aggression, body temperature, mood, sleep, human sexuality, appetite, and metabolism, as well as stimulating vomiting. Clinical studies have shown that supplementing with 5-HTP produces positive results in weight loss, anxiety and depression.

Blueberry Fruit

They protect our bodies from damage by free radicals, unstable molecules that can damage cellular structures and contribute to aging and diseases like cancer.

Blueberries are believed to contain the highest antioxidant capacity of ALL commonly consumed fruits and vegetables. The main antioxidant compounds in blueberries belong to a large family of polyphenols, called flavonoids. One group of flavonoids in particular, anthocyanins, is thought to be responsible for much of the beneficial health effects. They have been shown to directly increase antioxidant levels inside the body. Because blueberries are high in antioxidants, they can help neutralize some of the free radicals that cause damage to our DNA.

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Add a Comment
  1. what animal product is used in the age pill? where does it come from?

    1. The AGE Pill contains no animal products, instead all ingredients are plant-based-free from any harmful chemicals or unnatural ingredients.

  2. Alpha-lipoic acid is known to bind to mercury in the body and can remain in the body only for three hours. if a person, who has mercury in his body, would take AGE pill as described on the label, does it mean that the mercury will be poured into the bloodstream, causing all kinds of neurotoxical symptoms? For that, any medications with alpha-lipoic acid should be taken every three hours. How do you know that AGE pill is safe for people who have mercury stored in their bodies? Assuming that not many people know about the possibility of having mercury in them.

    1. Suggest that you ask your question in this group Nataliya:

  3. Are there any side effects?

  4. How much Nicotinamide Riboside is in the A.G.E. pill? Please specify per-capsule or per-serving.
    Why no mention of this ingredient in the posted information above?

  5. I would like to know if the Age Pill contains Cobalamin, also known as B12 vitamin. If yes, what percentage? Thank you

  6. I just had a stroke caused by afib, is it safe for me to take with blood thinner, hbpressureand high cholesterol, thyroid and SSRI medications????Please advise. A thank you

  7. Niacin flush.

  8. I am already thin and find that the AGE pill is causing unwanted weight loss.
    What ingredient might be causing this?
    Is there any way to work around this?
    ……Perhaps another Sisel product might be effective?

  9. If there are no animal sources for the ingredients in A.G.E, then what is the source for DMAE (dimethylaminoethanol) which was reported as coming from brains, anchovies and sardines?

  10. Hi,
    My father has Pulmonary Fibrosis. Can Sisel help that?

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